Targeting Dysregulated Transcription in Cancer Through Cyclin-Dependent-Kinase 11

A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation

JR Devlin, B Martin, N Bartonicek, K Ting, Z Fan, I Todorovski, F Bjelosevic, S Verschoor, A Ciccone, JA Trapani, A Horvath, E Tinsley, P Fraser, A Newbold, JJ Sandow, A Muscat, KJ Simpson, M Geyer, SJ Vervoort, RW Johnstone

2025-09-04

Controlled gene expression is achieved through the intricate regulation of RNA polymerase II (Pol II) progression through transcri..